Understanding Virulence of Invasive Staphylococcus Aureus

Grant number: 1145631 | Funding period: 2018 - 2020

Completed

Abstract

Staph aureus (Golden staph) is a major cause of disease in humans. In this project we will use state-of-the-art molecular biology and genomics to fully understand the mechanisms of virulence in this pathogen. This information will inform future approaches to development of therapeutics, as well as the use of genomics in clinical microbiology and disease management.

Related publications (6)

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GROND: a quality-checked and publicly available database of full-length 16S-ITS-23S rRNA operon sequences

CJ Walsh, M Srinivas, TP Stinear, D van Sinderen, PD Cotter, JG Kenny

2024-06-01

Sequence comparison of 16S rRNA PCR amplicons is an established approach to taxonomically identify bacterial isolates and profile ..

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A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

A Hachani, SG Giulieri, R Guérillot, CJ Walsh, M Herisse, YM Soe, SL Baines, DR Thomas, SD Cheung, AS Hayes, E Cho, HJ Newton, S Pidot, RC Massey, BP Howden, TP Stinear

2023-06-08

Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. aureus c..

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Reprogramming of Cell Death Pathways by Bacterial Effectors as a Widespread Virulence Strategy

JJ Wanford, A Hachani, C Odendall

2022-05-01

The modulation of programmed cell death (PCD) processes during bacterial infections is an evolving arms race between pathogens and..

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Intracellular Staphylococcus aureus and host cell death pathways

YM Soe, S Bedoui, TP Stinear, A Hachani

2021-05-01

Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have c..

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Comprehensive genomic investigation of adaptive mutations driving the low-level oxacillin resistance phenotype in staphylococcus aureus

SG Giulieri, R Guérillot, JC Kwong, IR Monk, AS Hayes, D Daniel, S Baines, NL Sherry, NE Holmes, P Ward, W Gao, T Seemann, TP Stinear, BP Howden

2020-11-01

Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of invasive methicillin-susceptible Stap..

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From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System

TE Wood, E Aksoy, A Hachani

2020-10-19

The health of mammals depends on a complex interplay with their microbial ecosystems. Compartments exposed to external environment..

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